Treatment in Neuromyelitis Optica
نویسندگان
چکیده
Background: The effects of interferon1b (IFN1b ) administration in multiple sclerosis (MS) patients have been confirmed, however, those in neuromyelitis optica (NMO) patients have not been shown. In this study, we assessed the effects of IFN1b treatment on disease exacerbation and disability progression in MS or NMO patients. Methods: We reviewed a series of 104 consecutive patients with relapsingremitting MS (RRMS) (69) or NMO (35) treated with IFN1b in the MS clinical center of a national hospital in Japan. Results: The relapse number in the RRMS patients significantly decreased within 1 year after IFN1b treatment (p ! 0.00001); however, that in the NMO patients did not show a significant decrease (p = 0.5601). The decrease in annualized relapse rates in each RRMS patient after treatment was significant (p ! 0.01), but that in each NMO patient was not (p 1 0.05). The change in Kurtzke’s Expanded Disability Status Scale score 1 year after treatment was higher in the NMO patients than in the RRMS patients (p = 0.0225). Conclusion: In NMO patients, IFN1b treatment was not effective in reducing the relapse number and the disability progression. Copyright © 2009 S. Karger AG, Basel Received: June 17, 2008 Accepted: May 11, 2009 Published online: July 7, 2009 Dr. M. Tanaka 8 Ondoyama, Narutaki, Ukyo-ku Kyoto 616-8255 (Japan) Tel. +81 75 461 5121, Fax +81 75 464 0027 E-Mail [email protected] © 2009 S. Karger AG, Basel 0014–3022/09/0623–0167$26.00/0 Accessible online at: www.karger.com/ene Tanaka /Tanaka /Komori Eur Neurol 2009;62:167–170 168 small. We reviewed the medical records of our Japanese patients with NMO and determined whether IFN1b treatment affects disease exacerbation and disability progression as indicated by an increase in Kurtzke’s Expanded Disability Status Scale (EDSS) score [7] in patients with NMO.
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